In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called New 3-O-substituted xanthone derivatives as promising acetylcholinesterase inhibitors, published in 2021, which mentions a compound: 16400-32-1, mainly applied to xanthone preparation acetylcholinesterase inhibitor structure activity; kinetic study enzyme inhibition xanthone acetylcholinesterase; Alzheimer’s disease; enzyme kinetic study; molecular docking; structure–activity relationship study; synthesis, Quality Control of 1-Bromo-2-pentyne.
A new series of 3-O-substituted xanthone derivatives I (R = H, Bu, 2-butynyl, CH2Ph, etc.) were synthesized and evaluated for their anti-cholinergic activities against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). The results indicated that the xanthone derivatives possessed good AChE inhibitory activity with eleven of them exhibiting significant effects with the IC50 values ranging from 0.88 to 1.28μM. The AChE enzyme kinetic study of 3-(4-phenylbutoxy)-9H-xanthen-9-one and Et 2-[(9-oxo-9H-xanthen-3-yl)oxy]acetate showed a mixed inhibition mechanism. A mol. docking study showed that 3-(4-phenylbutoxy)-9H-xanthen-9-one binds to the active site of AChE and interacts via extensive π-π stacking with the indole and phenol side chains of Trp86 and Tyr337, besides the hydrogen bonding with the hydration site and π-π interaction with the phenol side chain of Y72. This study revealed that 3-O-alkoxyl substituted xanthone derivatives are potential lead structures, especially 3-(4-phenylbutoxy)-9H-xanthen-9-one and Et 2-[(9-oxo-9H-xanthen-3-yl)oxy]acetate which can be further developed into potent AChE inhibitors.
When you point to this article, it is believed that you are also very interested in this compound(16400-32-1)Quality Control of 1-Bromo-2-pentyne and due to space limitations, I can only present the most important information.
Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics