With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14774-37-9,Tetrahydropyran-4-methanol,as a common compound, the synthetic route is as follows.
Preparation 4: Methanesulfonic acid (tetrahydropyran-4-yl)methyl ester To a mixture of Preparation 3 (216.5g, 1.87mol) and triethylamine (299mL) in DCM (1.3L) at <10C was added under argon a solution of methanesulfonyl chloride (236g, 16OmL) in DCM (20OmL) over 2h 50min, maintaining the temperature at 5-1O0C throughout. Subsequent washing with water (IL), IM HCl (50OmL), 5% NaHCO3 (30OmL), water(30OmL), drying (MgSO4) and then removal of the solvent afforded the title compound (328g, 90% yield). NMR was consistent with the above structure., 14774-37-9
The synthetic route of 14774-37-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Prosidion Ltd; WO2007/51845; (2007); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics