Some tips on 14774-37-9

The synthetic route of 14774-37-9 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14774-37-9,Tetrahydropyran-4-methanol,as a common compound, the synthetic route is as follows.

Preparation 4: Methanesulfonic acid (tetrahydropyran-4-yl)methyl ester To a mixture of Preparation 3 (216.5g, 1.87mol) and triethylamine (299mL) in DCM (1.3L) at <10C was added under argon a solution of methanesulfonyl chloride (236g, 16OmL) in DCM (20OmL) over 2h 50min, maintaining the temperature at 5-1O0C throughout. Subsequent washing with water (IL), IM HCl (50OmL), 5% NaHCO3 (30OmL), water(30OmL), drying (MgSO4) and then removal of the solvent afforded the title compound (328g, 90% yield). NMR was consistent with the above structure., 14774-37-9

The synthetic route of 14774-37-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Prosidion Ltd; WO2007/51845; (2007); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics