25637-16-5, 4-Bromotetrahydropyran is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Add 4-oxo-5- (p-tolyl) -1,4-dihydropyridazine-3-carboxylic acid ethyl (1.15 g, 4.452 mmol, 1.0 eq) and 4-bromotetrahydro-2H-pyran ( 882.0mg, 5.343mmol, 1.2eq) was dissolved in N, N-dimethylformamide (10.0mL), cesium carbonate (4.352g, 13.356mmol, 3.0eq) was added, and the temperature was raised to 100 C for 2h. TLC showed the reaction After completion, the reaction solution was filtered and concentrated under reduced pressure to remove N, N-dimethylformamide. Ethyl acetate was added, washed four times with water, dried, and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (DCM: MeOH = 200: 1). ~ 30: 1) to obtain the product (1.0g, yield: 87.0%).
25637-16-5, 25637-16-5 4-Bromotetrahydropyran 13349654, aTetrahydropyrans compound, is more and more widely used in various fields.
Reference£º
Patent; Nanjing Yaojie Good Health Biological Technology Co., Ltd.; Wu Yongqian; Li Lin; Wan Zhonghui; (107 pag.)CN110041316; (2019); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics