Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Journal of Enzyme Inhibition and Medicinal Chemistry called New 3-O-substituted xanthone derivatives as promising acetylcholinesterase inhibitors, Author is Loh, Zi Han; Kwong, Huey Chong; Lam, Kok Wai; Teh, Soek Sin; Ee, Gwendoline Cheng Lian; Quah, Ching Kheng; Ho, Anthony Siong Hock; Mah, Siau Hui, which mentions a compound: 16400-32-1, SMILESS is CCC#CCBr, Molecular C5H7Br, Recommanded Product: 1-Bromo-2-pentyne.
A new series of 3-O-substituted xanthone derivatives I (R = H, Bu, 2-butynyl, CH2Ph, etc.) were synthesized and evaluated for their anti-cholinergic activities against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). The results indicated that the xanthone derivatives possessed good AChE inhibitory activity with eleven of them exhibiting significant effects with the IC50 values ranging from 0.88 to 1.28μM. The AChE enzyme kinetic study of 3-(4-phenylbutoxy)-9H-xanthen-9-one and Et 2-[(9-oxo-9H-xanthen-3-yl)oxy]acetate showed a mixed inhibition mechanism. A mol. docking study showed that 3-(4-phenylbutoxy)-9H-xanthen-9-one binds to the active site of AChE and interacts via extensive π-π stacking with the indole and phenol side chains of Trp86 and Tyr337, besides the hydrogen bonding with the hydration site and π-π interaction with the phenol side chain of Y72. This study revealed that 3-O-alkoxyl substituted xanthone derivatives are potential lead structures, especially 3-(4-phenylbutoxy)-9H-xanthen-9-one and Et 2-[(9-oxo-9H-xanthen-3-yl)oxy]acetate which can be further developed into potent AChE inhibitors.
Compounds in my other articles are similar to this one(1-Bromo-2-pentyne)Recommanded Product: 1-Bromo-2-pentyne, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.
Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics