The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Ethyl indoline-2-carboxylate( cas:50501-07-0 ) is researched.Product Details of 50501-07-0.Ertugrul, Berrak; Kilic, Haydar; Lafzi, Farrokh; Saracoglu, Nurullah published the article 《Access to C5-Alkylated Indolines/Indoles via Michael-Type Friedel-Crafts Alkylation Using Aryl-Nitroolefins》 about this compound( cas:50501-07-0 ) in Journal of Organic Chemistry. Keywords: zinc triflate catalyzed Michael Friedel Crafts alkylation benzylindoline arylnitroolefin; benzylindoline zinc triflate catalyzed alkylation aryl nitroolefin; indoline preparation reaction; indole benzyl preparation. Let’s learn more about this compound (cas:50501-07-0).
A straightforward synthetic route toward C5-alkylated indolines/indoles has been developed. The strategy is composed of Zn(OTf)2-catalyzed Friedel-Crafts alkylation of N-benzylindolines with nitroolefins, and a series of diverse indolines was first obtained in up to 99% yield. This reaction provides a direct and practical route to a variety of the C5-alkylated indolines which were also utilized for accessing corresponding indoles. Indoline derivatives with free NH groups could be obtained through an N-deprotection reaction. Moreover, the primary alkyl nitro groups in both indolines and indoles are amenable to further synthetic elaborations, thereby broadening the diversity of the products.
Although many compounds look similar to this compound(50501-07-0)Product Details of 50501-07-0, numerous studies have shown that this compound(SMILES:O=C(C1NC2=C(C=CC=C2)C1)OCC), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics