With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.951127-25-6,tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate,as a common compound, the synthetic route is as follows.
At room temperature, 2b (0.2 g, 0.92 mmol) was dissolved in dimethylacetamide (4 mL)Intermediate 1 (0.275 g, 0.84 mmol) and benzenesulfonic acid (0.187 g, 1.01 mmol) were added and stirred at room temperature for 2 hours.Sodium tris (acetoxy) borohydride (0.231 g, 1.09 mmol) was added to the reaction solution, and the reaction was continued at room temperature for 16 hours.After cooling to 0 C, water (15 mL) and ammonia (1 mL) were added successively to precipitate a white solid.The reaction solution was filtered and the filter cake was washed with water (5 mL x 2), dried, and the filter cake was dried to give the white solid 2c (0.22 g, yield 49.5%).
951127-25-6 tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate 44193925, aTetrahydropyrans compound, is more and more widely used in various.
Reference£º
Patent; Sichuan Haisco Pharmaceutical Co.,Ltd; FAN, JIANG; CHEN, QINGPING; JIANG, WEI; ZHENG, SUXIN; YE, FEI; (128 pag.)TW2017/8221; (2017); A;,
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