Reference of Ethyl indoline-2-carboxylate. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Ethyl indoline-2-carboxylate, is researched, Molecular C11H13NO2, CAS is 50501-07-0, about Introduction of heterocycles at the 2-position of indoline as ester bioisosteres. Author is Lee, Sunkyung; Yi, Kyu Yang; Yoo, Sung-eun.
Compounds were prepared with heterocyclic replacements for metabolically unstable esters of benzopyranyl indole-2-carboxylic esters, which showed good in vitro and in vivo cardioprotective efficacies possibly through the opening of mitochondrial ATP-sensitive potassium channel (KATP). Initially, indolin-2-yl-heterocycles were constructed using unprotected indoline-2-carboxylic acid, but the cyclization was proceeded with oxidation of the indoline ring to the indole, which did not react with benzopyranyl epoxide. An N-BOC group was introduced to deplete the electron d. of the indoline ring. Various indolin-2-yl-heterocycles, such as I and II, were prepared by the cyclization of the building blocks including carboxamide, β-hydroxy amide, hydrazide, nitrile starting from N-BOC-indoline-2-carboxylic acid.
After consulting a lot of data, we found that this compound(50501-07-0)Reference of Ethyl indoline-2-carboxylate can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics