So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Le, Christine M.; Hou, Xiao; Sperger, Theresa; Schoenebeck, Franziska; Lautens, Mark researched the compound: 1,3,5,7-Tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantane( cas:97739-46-3 ).Recommanded Product: 1,3,5,7-Tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantane.They published the article 《An Exclusively trans-Selective Chlorocarbamoylation of Alkynes Enabled by a Palladium/Phosphaadamantane Catalyst》 about this compound( cas:97739-46-3 ) in Angewandte Chemie, International Edition. Keywords: stereoselective synthesis chloromethyleneoxindole; oxindole chloromethylene stereoselective synthesis; palladium phosphaadamantane catalyst chlorocarbamoylation alkyne; chlorocarbamoylation; cyclization; homogenous catalysis; palladium; phosphaadamantane. We’ll tell you more about this compound (cas:97739-46-3).
Pharmaceutically relevant methylene oxindoles are synthesized by a palladium(0)-catalyzed intramol. chlorocarbamoylation reaction of alkynes. A relatively underexplored class of caged phosphine ligands is uniquely suited for this transformation, enabling high levels of reactivity and exquisite trans selectivity. E.g., in presence of Pd2(dba)3 and 1,3,5,7-tetramethyl-2,4,6-trioxa-8-phenyl-6-phosphaadamantane in toluene, intramol. chlorocarbamoylation of 2-TIPSCCC6H4NBnCOCl gave 96% 3-(chloromethylene)oxindole derivative (E)-I. This report entails the first transition-metal-catalyzed atom-economic addition of a carbamoyl chloride across an alkyne.
After consulting a lot of data, we found that this compound(97739-46-3)Recommanded Product: 1,3,5,7-Tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantane can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics