With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14774-37-9,Tetrahydropyran-4-methanol,as a common compound, the synthetic route is as follows.
To a solution of (tetrahydro-2H-pyran-4-yl)methanol (1 g, 8.61 mmol) and TEA (2.400 mL, 17.22 mmol) in THF (15 mL) was added dropwise Ms-Cl (1.006 mL, 12.91 mmol) at 0 C. The reaction mixture was stirred for 20 hours at 25 C. The reaction mixture was poured into water (20 mL), extracted by EtOAc (30 mL), washed with 1M HC1 (5 ml), sat NaElCCh, (10 ml) and brine (10 ml). The organic layer was dried over Na2S04, filtered and concentrated to give (tetrahydro-2H-pyran-4-yl)methylmethanesulfonate (1.1 g, 5.21 mmol, 60.6 % yield) as a brown oil which was used in the next step without purification.
14774-37-9, 14774-37-9 Tetrahydropyran-4-methanol 2773573, aTetrahydropyrans compound, is more and more widely used in various fields.
Reference£º
Patent; VIIV HEALTHCARE UK (NO.5) LIMITED; BELEMA, Makonen; EASTMAN, Kyle J.; KADOW, John F.; GILLIS, Eric P.; NAIDU, B. Narasimhulu; PARCELLA, Kyle E.; (0 pag.)WO2020/3093; (2020); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics