In 2019,Journal of Organic Chemistry included an article by Castroagudin, Marina; Lobato, Ruben; Martinez-Garcia, Lucas; Sardina, F. Javier; Paleo, M. Rita. Recommanded Product: 25637-16-5. The article was titled 《Bis-enolates with extended π-conjugation are powerful nucleophiles. Study of their alkylation reactions with very hindered C-electrophiles》. The information in the text is summarized as follows:
Bis-enolates with extended π-conjugation, prepared by alkali metal mediated reduction of several aromatic and unsaturated diesters, can be efficiently and regioselectively alkylated with very hindered C-electrophiles, such as neopentyl, secondary and tertiary alkyl halides and tosylates. A one-step synthesis of 4-alkyl phthalates was derived from the reductive-alkylation of a phthalate diester with hindered halides followed by rearomatization with oxygen. Addnl., synthetic protocols have been developed to efficiently prepare complex fused- or spiro-bicycles from diisopropyl phthalate in just one or two steps. The experimental process involved the reaction of 4-Bromotetrahydropyran(cas: 25637-16-5Recommanded Product: 25637-16-5)
4-Bromotetrahydropyran(cas: 25637-16-5) is often used as reactant for: nickel-catalyzed alkyl-alkyl Suzuki coupling reactions with boron reagents, preparation of a selective small-molecule melanocortin-4 receptor agonist with efficacy in a pilot study of sexual dysfunction in humans; preparation of aliphatic hydrocarbons via nickel-catalyzed Suzuki cross-coupling with alkylboranes.Recommanded Product: 25637-16-5
Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics