In 2018,Chemical Science included an article by ElMarrouni, Abdellatif; Ritts, Casey B.; Balsells, Jaume. HPLC of Formula: 25637-16-5. The article was titled 《Silyl-mediated photoredox-catalyzed Giese reaction: addition of non-activated alkyl bromides》. The information in the text is summarized as follows:
Two series of substituted methyl-N-phenyl-propanamides I [R = cyclopropylmethyl, cyclohexylmethyl, (CH2)3Ph, etc.; R1 = Me] and alkyl esters II [R2 = (CH2)3Ph, tetrahydropyran-4-yl, 1-benzoyl-4-piperidyl, etc.; R3 = H, Me, CO2Et; X = OMe, OEt, OBn, etc.] was synthesized via silyl-mediated Giese addition reaction of non-activated alkyl bromides and Michael acceptors under visible-light photoredox catalysis. Optimization of the reaction was achieved using high-throughput experimentation (HTE) tools to enable the identification of mild, general and practical reaction conditions. A diverse set of alkyl bromides was successfully added to cyclic or acyclic α, β-unsaturated esters and amides. The features of this transformation allowed also access to a key intermediate I [R = (CH2)3CO2Me; R1 = H] of Vorinostat, an HDAC inhibitor used to fight cancer and HIV. The experimental process involved the reaction of 4-Bromotetrahydropyran(cas: 25637-16-5HPLC of Formula: 25637-16-5)
4-Bromotetrahydropyran(cas: 25637-16-5) is often used as reactant for: preparation of anthranilic acids as antibacterial agents with human serum albumin binding affinity; preparation of antiatherogenic antioxidant di-tert-butyldihydrobenzofuranols via Grignard reactions with di-tert-butyl(hydroxy)benzaldehyde derivatives; synthesis of gephyrotoxin via the Schmidt reaction.HPLC of Formula: 25637-16-5
Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics