In 2022,Yan, Xingxiu; Wang, Shengchun; Liu, Zhao; Luo, Yujie; Wang, Pengjie; Shi, Wenyan; Qi, Xiaotian; Huang, Zhiliang; Lei, Aiwen published an article in Science China: Chemistry. The title of the article was 《Precise electro-reduction of alkyl halides for radical defluorinative alkylation》.Reference of 4-Bromotetrahydropyran The author mentioned the following in the article:
A precise electro-reduction strategy for radical defluorinative alkylation towards the synthesis of gem-difluoroalkenes from α-trifluoromethylstyrenes was reported. According to the redox-p.d. of the radical precursors, direct or indirect electrolysis was resp. adopted to realize the precise reduction An easy-to-handle, catalyst- and metal-free condition was developed for the reduction of alkyl radical precursors that are generally easier to be reduced than α-trifluoromethylstyrenes, while a novel electro-Ni-catalytic system was established for the electro-reduction of alkyl bromides or chlorides towards the electrochem. synthesis of gem-difluoroalkenes. The merit of this protocol was exhibited by its mild conditions, wide substrate scope, and scalable preparation Mechanistic studies and DFT calculations proved that the coordination of α-trifluoromethylstyrenes to Ni-catalyst prevents the direct reduction of the alkene and, in turn, promotes the activation of alkyl bromide through halogen atom transfer mechanism.4-Bromotetrahydropyran(cas: 25637-16-5Reference of 4-Bromotetrahydropyran) was used in this study.
4-Bromotetrahydropyran(cas: 25637-16-5) is often used as reactant for: preparation of anthranilic acids as antibacterial agents with human serum albumin binding affinity; preparation of antiatherogenic antioxidant di-tert-butyldihydrobenzofuranols via Grignard reactions with di-tert-butyl(hydroxy)benzaldehyde derivatives; synthesis of gephyrotoxin via the Schmidt reaction.Reference of 4-Bromotetrahydropyran
Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics