In 2017,Zidan, M.; McCallum, T.; Thai-Savard, L.; Barriault, L. published 《Photoredox meets gold Lewis acid catalysis in the alkylative semipinacol rearrangement: A photocatalyst with a dark side》.Organic Chemistry Frontiers published the findings.Quality Control of 4-Bromotetrahydropyran The information in the text is summarized as follows:
The alkylative semipinacol rearrangement of a variety of TMS protected α-styrenyl substituted cyclic alcs. with unactivated bromoalkanes that merge photoredox and Au(I)/Au(III) catalysis has been achieved. This redox neutral rearrangement is marked by a dimeric Au(I) photocatalyst that plays two roles; photoredox activation of bromoalkanes and Au(III)-mediated semipinacol rearrangement coupled with C(sp3)-C(sp3) reductive elimination; a reaction mode rarely accessed. This operationally simple methodol. contains readily available starting materials that undergo reaction with [Au2(dppm)2]Cl2 upon irradiation with UVA LEDs, furnishing diversified ketone products. Primary, secondary, and tertiary bromoalkanes and a range of TMS protected α-styrenyl substituted alcs. were investigated in this transformation. In the experimental materials used by the author, we found 4-Bromotetrahydropyran(cas: 25637-16-5Quality Control of 4-Bromotetrahydropyran)
4-Bromotetrahydropyran(cas: 25637-16-5) is often used as reactant for: nickel-catalyzed alkyl-alkyl Suzuki coupling reactions with boron reagents, preparation of a selective small-molecule melanocortin-4 receptor agonist with efficacy in a pilot study of sexual dysfunction in humans; preparation of aliphatic hydrocarbons via nickel-catalyzed Suzuki cross-coupling with alkylboranes.Quality Control of 4-Bromotetrahydropyran
Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics