《Modular Synthesis of Multifunctionalized CF3-Allenes through Selective Activation of Saturated Hydrocarbons》 was written by Liu, Wenfeng; Liu, Chuhan; Wang, Minyan; Kong, Wangqing. Related Products of 25637-16-5This research focused ontrifluoromethylallene preparation regioselective DFT study; trifluoromethylenyne hydrocarbon electrophile three component dicarbofunctionalization photoaddn nickel catalyst. The article conveys some information:
The combination of decatungstate photo-hydrogen atom transfer and nickel catalysis, a three-component 1,4-dicarbofunctionalization of 2-trifluoromethyl-1,3-enynes RCCC(=CH2)CF3[R = Ph, 3-methoxy-2-(methoxycarbonyl)-3-oxopropyl, 2-(1-methyl-2,5-dioxocyclopentyl)ethyl, etc.] was achieved. This strategy allows the modular synthesis of tetrasubstituted CF3-allenes R1CH2C(CF3)=C=C(R)(R2) [R1 = dimethyl(phenyl)silyl, cyclohexyl, 2H-1,3-benzodioxol-2-yl, etc.; R2 = 4-(ethoxycarbonyl)benzen-1-yl, 6-methoxypyridin-3-yl, (4-fluorophenyl)carbonyl, etc.] under exceptionally mild conditions. A variety of electrophiles R2X (X = Br, Cl) was successfully employed as traps to lead to the desired products. Another significant advantage is that the most abundant hydrocarbons are used as feedstocks, and a wide range of synthetically versatile functional groups and complex drug-like structures can be easily incorporated. Based on exptl. and d. functional theory calculations, a possible catalytic cycle involving 1,3-nickel rearrangement is proposed. The results came from multiple reactions, including the reaction of 4-Bromotetrahydropyran(cas: 25637-16-5Related Products of 25637-16-5)
4-Bromotetrahydropyran(cas: 25637-16-5) is often used as reactant for: preparation of anthranilic acids as antibacterial agents with human serum albumin binding affinity; preparation of antiatherogenic antioxidant di-tert-butyldihydrobenzofuranols via Grignard reactions with di-tert-butyl(hydroxy)benzaldehyde derivatives; synthesis of gephyrotoxin via the Schmidt reaction.Related Products of 25637-16-5
Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics