Li, Gang’s team published research in Organic Letters in 2017 | CAS: 25637-16-5

4-Bromotetrahydropyran(cas: 25637-16-5) is often used as reactant for: preparation of anthranilic acids as antibacterial agents with human serum albumin binding affinity; preparation of antiatherogenic antioxidant di-tert-butyldihydrobenzofuranols via Grignard reactions with di-tert-butyl(hydroxy)benzaldehyde derivatives; synthesis of gephyrotoxin via the Schmidt reaction.Formula: C5H9BrO

In 2017,Li, Gang; Gao, Panpan; Lv, Xulu; Qu, Chen; Yan, Qingkai; Wang, Ya; Yang, Suling; Wang, Junjie published 《Synthesis of m-Alkylphenols via a Ruthenium-Catalyzed C-H Bond Functionalization of Phenol Derivatives》.Organic Letters published the findings.Formula: C5H9BrO The information in the text is summarized as follows:

In the presence of [RuCl2(p-cymene)]2 and 1-adamantanecarboxylic acid, aryl 2-pyridinyl ethers underwent regioselective alkylation with secondary and tertiary alkyl bromides mediated by K2CO3 in benzene to provide m-alkylaryl 2-pyridinyl ethers in 33-73% yields; N-methylation of the pyridine moiety with Me triflate followed by hydrolysis yielded m-alkylated phenols such as 3-tert-butylphenol in 74-82% yields. The method was used to prepare the pesticide etoxazole via 3-tert-butylphenol. A (p-cymene)ruthenium complex of 2-phenoxypyridine was prepared and underwent regioselective alkylation to give 3-(3-pentyl)phenyl 2-pyridinyl ether under the standard reaction conditions; addition of TEMPO, BHT, or benzoquinone inhibited the reaction. The structure of the (p-cymene)ruthenium complex of 2-phenoxypyridine was determined by X-ray crystallog. After reading the article, we found that the author used 4-Bromotetrahydropyran(cas: 25637-16-5Formula: C5H9BrO)

4-Bromotetrahydropyran(cas: 25637-16-5) is often used as reactant for: preparation of anthranilic acids as antibacterial agents with human serum albumin binding affinity; preparation of antiatherogenic antioxidant di-tert-butyldihydrobenzofuranols via Grignard reactions with di-tert-butyl(hydroxy)benzaldehyde derivatives; synthesis of gephyrotoxin via the Schmidt reaction.Formula: C5H9BrO

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics