《Cyclometalated Ruthenium Catalyst Enables Ortho-Selective C-H Alkylation with Secondary Alkyl Bromides》 was published in Chem in 2020. These research results belong to Wang, Gang-Wei; Wheatley, Matthew; Simonetti, Marco; Cannas, Diego M.; Larrosa, Igor. HPLC of Formula: 25637-16-5 The article mentions the following:
The use of a cyclometalated Ru-complex, RuBnN, as the catalyst results in a complete switch of the inherent meta-selectivity to ortho selectivity in the Ru-catalyzed sp2 C-H alkylation reaction with unactivated secondary alkyl halides was demonstrated. The high catalytic activity of RuBnN allowed mild reaction conditions that resulted in a transformation of broad scope and versatility. Preliminary mechanistic studies suggested that a bis-cycloruthenated species was the key intermediate undergoing oxidative addition with the alkyl bromides, thus avoiding the more common SET pathway associated with meta-selectivity. The results came from multiple reactions, including the reaction of 4-Bromotetrahydropyran(cas: 25637-16-5HPLC of Formula: 25637-16-5)
4-Bromotetrahydropyran(cas: 25637-16-5) is often used as reactant for: preparation of anthranilic acids as antibacterial agents with human serum albumin binding affinity; preparation of antiatherogenic antioxidant di-tert-butyldihydrobenzofuranols via Grignard reactions with di-tert-butyl(hydroxy)benzaldehyde derivatives; synthesis of gephyrotoxin via the Schmidt reaction.HPLC of Formula: 25637-16-5
Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics