With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.951127-25-6,tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate,as a common compound, the synthetic route is as follows.,951127-25-6
22c (0.270 g, 0.720 mmol) was dissolved in dimethylacetamide (5 mL) at room temperature,Intermediate 1 (0.170 g, 0.540 mmol) was added and stirred at room temperature for 1 hour.Sodium tris (acetoxy) borohydride (0.192 g, 0.910 mmol) was added to the reaction solution, and the reaction was stirred at room temperature for 16 hours.The reaction system was cooled to 0 C, water (10 mL) was added successively, and the pH was adjusted to 8 with aqueous ammonia (1 mL) to precipitate a white solid.The reaction solution was filtered and the cake was washed successively with water (5 mL x 3), petroleum ether (10 mL x 1).The filter cake was dried to give a pale white solid 22d (0.220 g, yield 79.7%).
As the paragraph descriping shows that 951127-25-6 is playing an increasingly important role.
Reference£º
Patent; Sichuan Haisco Pharmaceutical Co.,Ltd; FAN, JIANG; CHEN, QINGPING; JIANG, WEI; ZHENG, SUXIN; YE, FEI; (128 pag.)TW2017/8221; (2017); A;,
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