Thomas, Emmanuel published the artcileSynthesis and preliminary biological evaluation of new antiproliferative aromatic analogues of 1α,25-dihydroxyvitamin D3, Related Products of tetrahydropyran, the publication is European Journal of Medicinal Chemistry (2014), 381-393, database is CAplus and MEDLINE.
In an effort to develop novel vitamin D3 analogs, a series of aromatic compounds was synthesized, using efficient Negishi cross coupling between alkenylzinc reagents of the C,D-ring moiety of vitamin D3, and various substituted aromatic halides as A-ring mimics. The study aimed at exploring the influence of the replacement of the original vitamin D3 diene by a styrene unit on the biol. activities. Potency in the induction of the differentiation of HL-60 cells for the lead compound I was 12 fold less important than calcitriol correlating with a weaker binding affinity for VDR.
European Journal of Medicinal Chemistry published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C24H29N5O3, Related Products of tetrahydropyran.
Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics