Zhang, Baoshun published the artcileSynthesis and anti-hyperglycemic activity of hesperidin derivatives, COA of Formula: C16H14O6, the publication is Bioorganic & Medicinal Chemistry Letters (2012), 22(23), 7194-7197, database is CAplus and MEDLINE.
A series of hesperidin derivatives, e.g. I (R = H, Me), were prepared and identified by IR, 1H NMR, and MS spectra. These compounds were evaluated in vitro and in vivo based on α-glucosidase inhibition, glucose consumption of HepG2 cells, and blood glucose level in streptozotocin-induced diabetic mice. The results revealed that all the compounds exhibited anti-hyperglycemic activities. The inhibition at 10-3 M of compounds I (R = H, Me) on α-glucosidase were 55.02% and 53.34%, resp., as compared to 54.80% by acarbose. Treated by compound I (R = H) and the reference drug metformin, glucose consumption of HepG2 cell were 1.78 and 2.11 mM, resp. After the streptozotocin-induced diabetic mice were orally administered with compound I (R = H) at 100 mg kg-1 d-1 for 10 days, the blood glucose level of I (R = H) treated mice (13.23 mM, P <0.05) showed significant difference when compared to model control (23.03 mM). Thus, compound I (R = H) exhibited promising anti-hyperglycemic activity.
Bioorganic & Medicinal Chemistry Letters published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C10H16O2, COA of Formula: C16H14O6.
Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics