Zhen, Jing published the artcileSynthesis of novel flavonoid alkaloids as α-glucosidase inhibitors, Synthetic Route of 69097-99-0, the publication is Bioorganic & Medicinal Chemistry (2017), 25(20), 5355-5364, database is CAplus and MEDLINE.
A series of novel flavonoid alkaloids were synthesized with different flavonoids and attached nitrogen-containing moieties. These new compounds were screened for inhibitory activity of α-glucosidase, among which compound I was found to show the lowest IC50 of 4.13 μM. Kinetic anal. indicates that the synthesized compounds II and I inhibit the enzyme in a non-competitive model with Ki value of 37.8 ± 0.8 μM and 13.2 ± 0.6 μM. Further docking studies suggest that the preferred binding pocket is close to the catalytic center, correlating to the exptl. results. Structure activity relationship studies (SAR) indicate that 4′-hyroxyl group and the 4-position carbonyl group in the flavonoid structure are important for this biol. activity. Addition of extra hydrogen bonding and hydrophobic groups on ring A would increase the inhibitory activity.
Bioorganic & Medicinal Chemistry published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C7H11N3O, Synthetic Route of 69097-99-0.
Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics