Ali, Imran published the artcileChiral HPLC separation and simulation studies of two chiral centered bis-imino flavans (Schiff base), Product Details of C16H14O6, the publication is Microchemical Journal (2022), 107429, database is CAplus.
The biol. activities of flavanone and hesperetin were enhanced by synthesizing Schiff base types mols. (bis-imino-flavans; BHF4, BHF8 and BHF10) by combining flavanone and hesperetin. These mols. were characterized by spectroscopic studies. The four enantiomers of these mols. were separated by HPLC due to the presence of two chiral centers in these mols. The best separation was achieved with ChiralcelOD-H column under normal mobile phase mode. BHF4 and BHF8 racemates separated completely with k1, k2, k3 & k4; α1, α2 & α3 and Rs1, Rs2 & Rs3 values of 3.00, 3.55, 3.80 & 4.25; 1.18, 1.07 & 1.12 and 1.26, 1.10 & 1.00 for BHF4 while these values were 5.70, 6.30, 9.08 & 9.83; 1.11, 1.44 & 1.08 and 1.08, 1.37, 6.35 and 1.71. On the other hand, BHF10 could not sep. completely. The free energy (ΔG) was calculated for the best separation conditions, and the correlation accurately shows the favorable range of the intercalated length. The chiral mechanism was proposed based on the carbon lengths between flavanone and hesperetin mols. in bis-imino-flavans. The modeling results confirmed the binding order of the enantiomers in BHF4 > BHF8 > BHF10; with maximum bing of SR-enantiomers. The synthesized and separated Schiff base types bis-imino-flavans were evaluated in urine samples with satisfactory results.
Microchemical Journal published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Product Details of C16H14O6.
Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics