Qian, Xu-Xuan-Hong published the artcileExploration on antibacterial mechanism of Xiangsu Powder based on network pharmacology, Application In Synthesis of 69097-99-0, the publication is TMR Pharmacology Research (2021), 1(2), 11, database is CAplus.
To explore the antibacterial mechanism of the active components of Xiangsu powder through the network pharmacol. approach. TCMSP database was used to search and obtain the active components of Xiangsu powder and its corresponding action targets, and its network relationship was defined. Target points associated with antibacterial effect were searched in Genecards database, and core target genes of antibacterial effect were obtained by mapping the target points. Finally, the GO biol. process and KEGG metabolic pathway were analyzed in the DAVID database. There were 129 active components, 250 targets, and 66 biol. processes (40 biol. processes, 13 mol. functions, 13 cell compositions) and 35 related signaling pathways. Among them, quercetin may be the main substance that plays a role in the drugs contained in Xiangsu powder, followed by flavonol kaempferol and flavonoid luteolin. Antibacterial targets such as TNF, Casp3, PTGS2, ACTB, STAT1 and NFKB1 are mostly involved in antiviral, anti-inflammatory and immune pathways. It mainly plays a role in the hepatitis B pathway and tumor necrosis factor signaling pathway. Quercetin, kaempferol, luteolin and other active components in Xiangsu powder can participate in the action process of Toll-like receptor pathway, TNF signaling pathway and other pathways through acting on TNF, Casp3, PTGS2, etc., and finally achieve the purpose of antibacterial.
TMR Pharmacology Research published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Application In Synthesis of 69097-99-0.
Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics