Grue-Sorensen, Gunnar’s team published research in Bioorganic & Medicinal Chemistry in 6 | CAS: 27943-46-0

Bioorganic & Medicinal Chemistry published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, Safety of 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran.

Grue-Sorensen, Gunnar published the artcileNew 1α,25-dihydroxy vitamin D3 analogs with side chains attached to C-18: synthesis and biological activity, Safety of 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, the publication is Bioorganic & Medicinal Chemistry (1998), 6(11), 2029-2039, database is CAplus and MEDLINE.

A new class of analogs of 1α,25-dihydroxy vitamin D3 has been synthesized, in which the side chain (C-23 to C-27) has been removed and where new hydroxylated side chains have been attached to the C-18 Me group. These analogs, I [R = Me, Q = (CH2)3, (CH2)4, C6H4CH2-3, CCCH2, CH2CCCH2, CCCH2CH2; R = Et, Q = (CH2)3, C6H4CH2-3, CCCH2CH2], show antiproliferative activity in U937 and HaCaT cells comparable to that of 1α,25-dihydroxy vitamin D3. Lack of calcemic activity makes these analogs potentially useful in the treatment of proliferative diseases.

Bioorganic & Medicinal Chemistry published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, Safety of 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics