With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.125552-89-8,4-(Bromomethyl)tetrahydropyran,as a common compound, the synthetic route is as follows.
Example 78: Preparation of 5-[5-FIuoro-2-oxo-l,2-dihydro-indol-(3Z)- ylidenemethyll-2,4-dimethyl-lH-pyrrole-3-carboxylic acid [(S)-2,5-dioxo- 1- (tctrahydro-pyran-4-ylmethyl)-pyrrolidin-3-yl]-amide75C 60a yeaStepl : Compound 75c (200mg, 0.93mmol), 60a (201mg, 1.12mmol), KI (163mg, 0.98mmol), K2CO3 (644mg, 4.67mmol) and acetonitrile (2OmL) were mixed in a microwave vial. The resulting mixture was reacted under microwave condition at 14O0C for Ih. After being cooled, the mixture was filtered. The filtrate was evaporated and the residue was purified by column chromatography (EA::PE=1 :3) to provide 78a (224mg, 77%)., 125552-89-8
125552-89-8 4-(Bromomethyl)tetrahydropyran 2773286, aTetrahydropyrans compound, is more and more widely used in various fields.
Reference£º
Patent; XCOVERY, INC.; WO2008/33562; (2008); A2;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics