Galbraith, M. N.’s team published research in Experientia in 31 | CAS: 27943-46-0

Experientia published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, HPLC of Formula: 27943-46-0.

Galbraith, M. N. published the artcileInsect molting hormones. Synthesis and biological activity of 2,25-dideoxy-α-ecdysone and deoxyecdysone, HPLC of Formula: 27943-46-0, the publication is Experientia (1975), 31(8), 873, database is CAplus and MEDLINE.

Pregnenecarboxaldehyde I, obtained from ergosteryl acetate, was alkylated with Me2CHCCH, and then hydrolyzed to 3β,22(R)-dihydroxy-5β-cholest-7-en-23-yn-6-one (II). Hydrogenation of II over Pt gave 2,25-dideoxy-α-ecdysone (III). Alkylation of I with 3-methyl-3-(tetrahydropyranyloxy)-1-butyne followed by hydrolysis and hydrogenation gave 2-deoxy-α-ecdysone (IV). IV showed the same activity as β-ecdysone in the Calliphora biossay, whereas III had only half that of β-ecdysone.

Experientia published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, HPLC of Formula: 27943-46-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics