With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.693287-79-5,tert-Butyl 2-(tetrahydro-2H-pyran-4-yl)hydrazinecarboxylate,as a common compound, the synthetic route is as follows.
General procedure: To a stirred solution of N?-(tetrahydropyran-4-yl)hydrazinecarboxylic acid tert-butyl ester (7.9 g, 37 mmol) in DCM(30 mL) was added HC1/dioxane (4M, 30 mL) dropwise. The mixture was stirred at room temperature for 4 hrs. The suspended filtered to give the desired product (tetrahydro-pyran-4-yl)hydrazine (5.3 g, yield: 94.5 %) as white solid. ?HNMR (300 MI-Tz, DMSO-d6): oe = 3.68 (d,J= 5.4 Hz, 2H), 3.3 1-3.24 (m, 2H), 3.16-3.07 (m, 1H), 1.89(d, 2H), 1.48-1.39(m, 2H).
The synthetic route of 693287-79-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE; PINKERTON, Anthony, B.; HASSIG, Christian, A.; JACKSON, Michael, R.; ARDECKY, Robert, John; PASS, Ian; (436 pag.)WO2016/123392; (2016); A2;,
Tetrahydropyran – Wikipedia
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