Kihira, Kenji published the artcileComparative biological studies of bile alcohols. IV. New bile alcohols. Synthesis of (22R)- and (22S)-5β-cholestane-3α,7α,12α,22,25-pentols, Application of 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, the publication is Steroids (1976), 27(3), 383-93, database is CAplus and MEDLINE.
Bisnorcholanal I, prepared from triacetylcholic acid by successive oxidative-decarboxylation, alk. hydrolysis, treatment with H2O2, alk. hydrolysis, and oxidation with Pb(OAc)4, was treated with 3-methyl-3-(tetrahydropyran-2-yloxy)butynylmagnesium bromide. Hydrogenation over PtO2 of the epimeric acetylenes followed by acid hydrolysis gave (22R)- and (22S)-cholestanepentols II. (22R)-II was identical with the metabolite of 5β-cholestane-3α,7α,25-triol formed in the rabbit.
Steroids published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, Application of 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran.
Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics