With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.220641-87-2,N-Methyltetrahydro-2H-pyran-4-amine,as a common compound, the synthetic route is as follows.
Step a Intermediate 203 -Bromo-N-methyl-N-(tetrahydro-2H-pyran-4-yl)benzenesulfonaniide To a solution of N-methyltetrahydro-2H-pyran-4-amine (0.710 g, 6.16 mmol) and Et3N (1.227 ml, 8.81 mmol) in DCM (10 ml) cooled to 0 C was added dropwise a solution of 4-bromobenzene-l-sulfonyl chloride (1.5 g, 5.87 mmol) in DCM (10 ml). The reaction was allowed to warm to r.t. and stirred for 20 h. The reaction was concentrated under reduced pressure and the resultant white solid dissolved in EtOAc and filtered. The filtrate was concentrated under reduced pressure and the resulting solid dried under high vacuum to yield 4-bromo-N-methyl-N-(tetrahydro-2H-pyran-4- yl)benzenesulfonamide as an off-white solid (1.94 g, 99 %). ? NMR (400 MHz, DMSO- 57.79 (m, 4H), 3.87 – 4.01 (m, 1 H), 3.73 – 3.86 (m, 2H), 3.33 – 3.37 (m, 1H), 3.29 (m, 1H), 2.70 (s, 3H), 1.54 – 1 .70 (m, 2H), 1.11 – 1.27 (m, 2H)
220641-87-2, The synthetic route of 220641-87-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; RUPRAH, Parminder, Kaur; MERCHANT, Kevin, John; WALSH, Louise, Marie; KERR, Catrina, Morven; FIELDHOUSE, Charlotte; HARRISSON, David; MAINE, Stephanie; HAZEL, Katherine; WO2013/27001; (2013); A1;,
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