Zhang, Yuanyuan published the artcileMolecular mechanism of Sophora flavescens in treatment of liver cancer based on network pharmacology, Related Products of tetrahydropyran, the publication is Shijie Zhongyiyao (2021), 16(5), 751-757, database is CAplus.
Objective: To explore the mechanism of Sophora flavescens in the treatment of liver cancer by means of network pharmacol. Methods: First, the active ingredients and targets of Sophora flavescens were screened through the TCMSP platform. The disease targets were obtained from OMIM and Genecards. Genes were matched through R language, and a Venn diagram was drawn. An active ingredient-protein interaction network diagram was constructed on the String website. A component-target network with Cytoscape 3.6.1 software was constructed. GO enrichment anal. and KEGG pathway enrichment anal. were performed through R software. Results: A total of 45 active ingredients and 176 potential targets were screened. GO and KEGG function enrichment showed that Sophora flavescens mainly affected PI3K/Akt/mTOR pathway and HIF-1a signal pathways. Conclusion: Sophora flavescens may regulate the invasion and metastasis of liver cancer cells by affecting the PI3K/Akt/mTOR pathway and HIF-1a signaling pathways.
Shijie Zhongyiyao published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C14H28O5S, Related Products of tetrahydropyran.
Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics