108-55-4, Dihydro-2H-pyran-2,6(3H)-dione is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of (2.01 g, 5.46 mmol) of curcumin, and (112 mg, 0.92 mmol) of DMAP in 100 mL THF was added (1.33 mL, 9.55 mmol) of Et3N. (0.685 g, 6 mmol)glutaric anhydride (95%) in 5 mL THF was added slowly dropwise to the curcumin solution. The mixture was stirred and refluxed under argon overnight. THF was removed under vacuum, 55 mL EtOAc was added, followed by the addition of 15 mL1M HC1, the mixture was stirred for 10 minutes. The organic phase was separated and extracted with EtOAc three times; the solvent was removed and dried. The product was purified via column chromatography, eluting with CH2C12: MeOH, 95: 5. Yield:69 %. 1HNMR (CDC13, 400 MHz): oe 7.65 (d, J= 16Hz, 2H), 7.20-6.95 (m, 5H), 6.96 (d, 1H), 6.48-6.57 (m, 2H), 5.85 (s, 2H), 3.98 (s, 3H), 3.90 (s, 3H), 2.75-2.7 1 (t, J= 8 Hz, 2H), 2.61-2.57 (t, J= 8 Hz, 2H), 2.15-2.12 (t, J= 8 Hz, 2H). 13C NMR (CDC13, 100 MHz): oe 184.56, 181.80, 178.26, 170.84, 151.28, 148.03, 146.84, 141.09, 139.40,134.12, 127.53, 124.25, 123.07, 121.73, 120.99, 114.89, 111.37, 109.69, 101.58,55.96, 32.82, 19.92. LC-MS: 483 [M+Hj (figure 1).
108-55-4, As the paragraph descriping shows that 108-55-4 is playing an increasingly important role.
Reference£º
Patent; DONG SUNG PHARM. CO., LTD.; JALDE, Shivakumar S; KIM, Yong Wan; SON, Kwang Hee; LEE, Hwan Suk; (53 pag.)WO2018/236193; (2018); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics