With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.101691-94-5,4-(Iodomethyl)tetrahydro-2H-pyran,as a common compound, the synthetic route is as follows.
Ingenol-5f20-acetonide-3-(3f5-dimethyl-l-(tetrahvdropyran-4-ylmethynpyrazole-4- carboxylate) (Compound 661) Compound 661 was prepared by heating a mixture of ingenol-5,20-acetonide-3-(3,5- dimethyl-lH-pyrazole-4-carboxylate) (15 mg), 4-iodomethyl-tetrahydro-2H-pyran (80 mg) and potassium carbonate (40 mg) in Nu,Nu-dimethylformamide (0.5 ml) at 120 C in microwave oven for 20 min. Addition of water and extraction with dichloromethane, followed by evaporation of solvent, gave a crude product which was purified by chromatography as described in Procedure c to give the title compound. Ingenol-5,20- acetonide-3-(3,5-dimethyl-lH-pyrazole-4-carboxylate) was prepared by Procedure c with 3,5-dimethyl-lH-pyrazole-4-carboxylic acid as starting material., 101691-94-5
The synthetic route of 101691-94-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; LEO PHARMA A/S; GRUE-S?RENSEN, Gunnar; LIANG, Xifu; HOeGBERG, Thomas; MANSSON, Kristoffer; VEDS?, Per; VIFIAN, Thomas; WO2012/83953; (2012); A1;,
Tetrahydropyran – Wikipedia
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