Li, Xiaoxuan published the artcileEnantioseparation of single layer native cyclodextrin chiral stationary phases: Effect of cyclodextrin orientation and a modeling study, Safety of 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, the publication is Analytica Chimica Acta (2017), 174-184, database is CAplus and MEDLINE.
A novel native cyclodextrin (CD) chiral stationary phase (CSP) with single triazole-bridge at CD C2 position (CSP1) was prepared by anchoring mono(2A-azido-2A-deoxy)-β-CD onto alkynyl silica via click chem. The effect of CD orientation on single layer CD-CSP’s enantioseparation was comprehensively studied using CSP1 (reversed orientation) and the authors’ previously reported CSP2 (C6 single triazole-bridge, normal orientation) as well as a com. CD-CSP (Cyclobond I 2000, hybrid orientation) by separating several groups of analytes in chiral HPLC. The CD orientation on silica surface plays an important role in separating different racemates. CSP2 with normal CD orientation affords best separation for isoxazolines while CSP1 with reversed CD orientation better separates naringenin, hesperetin and Troger’s base. CSP2 and Cyclobond I 2000 show comparable separation ability for dansyl amino acids while poor separation was found on CSP1. Besides, mol. dynamics simulation was performed under real separation conditions using flavanone as model analyte to reveal the essential factors for CD’s chiral discrimination behaviors.
Analytica Chimica Acta published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Safety of 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one.
Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics