With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.951127-25-6,tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate,as a common compound, the synthetic route is as follows.
951127-25-6, A mixture of 1j (1165 mg, 2.236 mmol) and intermediate 1 (804.4 mg, 2.459 mmoL)Was dissolved in N, N-dimethylacetamide (10 mL)Stirred at room temperature for 0.5 hour,Under ice bath, tris (acetoxy) borohydride was added(1279 mg, 6.037 mmoL),After stirring at 0 C for 0.5 hour, the mixture was stirred at room temperature for 2 hours.Add intermediate 1 (400 mg, 1.223 mmoL)And tri (acetoxy) borohydride (400 mg, 1.887 mmoL)Room temperature reaction for 2 hours.The reaction solution was added to a saturated sodium bicarbonate solution (100 mL)Stirring for 0.5 hours,filter,The filter cake was washed with water (20 mL x 3) and dissolved in dichloromethane (100 mL)Dried over anhydrous sodium sulfate,filter,Spin dry,The residue was purified by silica gel column chromatography (dichloromethane / methanol (v / v) = 60: 1)The resulting crude product was dissolved in ether (50 mL)Was added n-hexane (100 mL)filter,A yellow solid was obtained 1 k (480 mg, yield 42%).
As the paragraph descriping shows that 951127-25-6 is playing an increasingly important role.
Reference£º
Patent; Sichuan Hai Sike Pharmaceutical Co., Ltd.; Fan Jiang; Chen Qingping; Wang Chengtao; (36 pag.)CN106632349; (2017); A;,
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