220641-87-2, N-Methyltetrahydro-2H-pyran-4-amine is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A mixture of -1- (4- (4-chloro-lH-pyrazol-l-yl) pyridin-3- yl) piperidine-4-carboxylic acid (0.50 g) , N-methyltetrahydro- 2H-pyran-4-amine (0.16 g) , HATU (0.81 g) , triethylamine (0.91 mL) and DMF (8.2 mL) was stirred at room temperature for 3 hr. To the mixture was added water, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and saturated brine, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (NH, ethyl acetate/hexane) , and the obtained solid was crystallized from ethyl acetate/hexane to give the title compound (0.43 g). XH NMR (300 MHz, CDC13) 51.45-1.65 (2H, m) , 1.65-2.11 (6H, m) , 2.61 (1H, brs), 2.71-2.97 (5H, m) , 3.13 (2H, d, J = 11.7 Hz), 3.37-3.59 (2H, m), 3.94-4.16 (2H, m) , 4.66-4.84 (1H, m) , 7.59 (1H, s), 7.66 (1H, s) , 8.40 (lH, s) , 8.46 (1H, s) , 8.59 (1H, s).
220641-87-2, The synthetic route of 220641-87-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; KOIKE, Tatsuki; IKEDA, Shuhei; WO2015/190613; (2015); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics