Gerona, Roy R. published the artcileBisphenol-A (BPA), BPA Glucuronide, and BPA Sulfate in Midgestation Umbilical Cord Serum in a Northern and Central California Population, Product Details of C21H24O8, the publication is Environmental Science & Technology (2013), 47(21), 12477-12485, database is CAplus and MEDLINE.
Bisphenol-A (BPA) is an endocrine disrupting chem. used in numerous consumer products, resulting in universal exposure in the United States. Prenatal exposure to BPA is associated with numerous reproductive and developmental effects in animals. However, little is known about human fetal exposure or metabolism of BPA during midgestation. In the present study, the authors present a new liquid chromatog.-tandem mass spectrometry method to directly measure concentrations of BPA and two predominant metabolic conjugates-BPA glucuronide and BPA sulfate-in umbilical cord serum collected from elective second trimester pregnancy terminations. The authors detected at least one form of BPA in all umbilical cord serum samples: BPA (GM 0.16, range < LOD-52.26 ng/mL), BPA glucuronide (GM 0.14, range < LOD-5.41 ng/mL) and BPA sulfate (GM 0.32, range < LOD-12.65 ng/mL). Levels of BPA ranged from less than 1/100th to over 400 times higher than levels of BPA in conjugated form. Although levels of BPA in conjugated form exceeded BPA levels in about 3/4 of the samples, BPA levels were higher in samples with total BPA above the median. The authors’ findings suggest universal fetal exposure to BPA in the authors’ study population, with some at relatively high levels, and the authors provide the first evidence of detectable BPA sulfate in midgestation fetuses.
Environmental Science & Technology published new progress about 267244-08-6. 267244-08-6 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Chiral,Carboxylic acid,Benzene,Phenol,Alcohol,Ether,, name is (2S,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-(4-(2-(4-hydroxyphenyl)propan-2-yl)phenoxy)tetrahydro-2H-pyran-2-carboxylic acid, and the molecular formula is C21H24O8, Product Details of C21H24O8.
Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics