Venkatesan, Aranapakam M. et al. published their research in Journal of Medicinal Chemistry in 2004 | CAS: 103260-44-2

Ethyl 2-(tetrahydro-2H-pyran-4-yl)acetate (cas: 103260-44-2) belongs to tetrahydropyran derivatives. Tetrahydropyrans and furans principally constitute as a central motif in diverse medicinally privileged molecules. There is large number of marine macrolide natural products that contain tetrahydropyran and tetrahydrofuran ring together. For instance, goniodomin A (actin targeting polyether), prorocentrolide (toxin halistatins), and percentotoxineFormula: C9H16O3

Synthesis and Structure-Activity Relationships of 4-alkynyloxy Phenyl Sulfanyl, Sulfinyl, and Sulfonyl Alkyl Hydroxamates as Tumor Necrosis Factor-α Converting Enzyme and Matrix Metalloproteinase Inhibitors was written by Venkatesan, Aranapakam M.;Davis, Jamie M.;Grosu, George T.;Baker, Jannie;Zask, Arie;Levin, Jeremy I.;Ellingboe, John;Skotnicki, Jerauld S.;DiJoseph, John F.;Sung, Amy;Jin, Guixian;Xu, Weixin;McCarthy, Diane Joseph;Barone, Dauphine. And the article was included in Journal of Medicinal Chemistry in 2004.Formula: C9H16O3 This article mentions the following:

A series of 4-alkynyloxy Ph sulfanyl, sulfinyl and sulfonyl alkyl and piperidine-4-carboxylic acid hydroxamides were synthesized. Their structure-activity relationships, against tumor necrosis factor-α (TACE) and matrix metalloproteinase (MMP) inhibitor activities, are presented by investigating the oxidation state on sulfur and altering the P1′ substituent. Sulfonyl compounds prepared for this series carrying a 4-butynyloxy moiety were selective TACE inhibitors over the MMPs tested. Sulfinyl compounds prepared for this series showed a preference for a specific oxidation on sulfur. The selectivity over MMPs was also demonstrated in the sulfonyl series. The enhanced cellular activity was achieved upon incorporating a butynyloxy substituent in the piperidine series. 4-[[4-(2-Butynyloxy)phenyl]sulfonyl]-N-hydroxy-1-[(4-methoxyphenyl)methyl]-4-piperidinecarboxamide (I) and 4-[[4-(2-butynyloxy)phenyl]sulfonyl]-1-[(4-chlorophenyl)methyl]-N-hydroxy-4-piperidinecarboxamide were potent inhibitors of TNF-α release in the mouse at 100 mg/kg po. In the experiment, the researchers used many compounds, for example, Ethyl 2-(tetrahydro-2H-pyran-4-yl)acetate (cas: 103260-44-2Formula: C9H16O3).

Ethyl 2-(tetrahydro-2H-pyran-4-yl)acetate (cas: 103260-44-2) belongs to tetrahydropyran derivatives. Tetrahydropyrans and furans principally constitute as a central motif in diverse medicinally privileged molecules. There is large number of marine macrolide natural products that contain tetrahydropyran and tetrahydrofuran ring together. For instance, goniodomin A (actin targeting polyether), prorocentrolide (toxin halistatins), and percentotoxineFormula: C9H16O3

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics