Kinetic resolution of racemic allylic alcohols via iridium-catalyzed asymmetric hydrogenation: scope, synthetic applications and insight into the origin of selectivity was written by Wu, Haibo;Margarita, Cristiana;Jongcharoenkamol, Jira;Nolan, Mark D.;Singh, Thishana;Andersson, Pher G.. And the article was included in Chemical Science in 2021.Related Products of 13417-49-7 This article mentions the following:
Herein, the first iridium catalyzed kinetic resolution of a wide range of trisubstituted secondary and tertiary allylic alcs. R1R4C=CR2CH(OH)R3 [R1 = Me, Ph, 2-thienyl, etc.; R2 = H, Me, Et, etc.; R3 = Et, i-Pr, Ph, etc.; R4 = H, Me] was described. Large selectivity factors were observed in most cases (s up to 211), providing the unreacted starting materials in good yield with high levels of enantiopurity (ee up to >99%). The utility of this method was highlighted in the enantioselective formal synthesis of some bioactive natural products including pumiliotoxin A, inthomycin A and B. DFT studies and a selectivity model concerning the origin of selectivity were also presented. In the experiment, the researchers used many compounds, for example, 5,6-Dihydro-2H-pyran-3-carbaldehyde (cas: 13417-49-7Related Products of 13417-49-7).
5,6-Dihydro-2H-pyran-3-carbaldehyde (cas: 13417-49-7) belongs to tetrahydropyran derivatives. Dihydropyrans and tetrahydropyrans are examples of cyclic ethers widespread in nature. The bismuth chloride-assisted cross-cyclization between homoallylic alcohols and epoxides provided various benzyl tetrahydropyran derivatives. The reaction afforded good yields of desired products and occurred under mild conditions.Related Products of 13417-49-7
Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics