Conducting Redox Polymer-Based Reagentless Biosensors Using Modified PQQ-Dependent Glucose Dehydrogenase was written by Habermueller, Katja;Reiter, Sabine;Buck, Harvey;Meier, Thomas;Staepels, Johnny;Schuhmann, Wolfgang. And the article was included in Microchimica Acta in 2003.Related Products of 14431-43-7 This article mentions the following:
Reagentless, oxygen-independent glucose biosensors based on an Os-complex-modified polypyrrole matrix and on soluble PQQ-dependent glucose dehydrogenase from Acinetobacter calcoaceticus are described. As the soluble form of glucose dehydrogenase from Acinetobacter calcoaceticus is a hydrophilic enzyme with a pos. net charge, its entrapment into the pos. charged hydrophobic polypyrrole film is much more complicated than that of the corresponding membrane enzyme or the neg. charged and very stable glucose oxidase. Possible ways for using soluble PQQ-dependent glucose dehydrogenase in combination with conducting polymer films are seen in the modulation of the enzyme properties by covalent binding of suitable compounds to the protein shell together with the adjustment of the properties of the conducting polymer film. This can be done by neutralizing the net charge of the protein and/or optimizing the electron-transfer pathway between enzyme and electrode surface by covalent binding of suitable redox relays to the protein surface. In addition, methods for increasing the hydrophilicity of the polymer film, such as the co-entrapment of high-mol. weight hydrophilic additives and copolymerization of hydrophilic pyrrole derivatives are presented. It is demonstrated that the replacement of the parent monomer pyrrole by a suitable hydrophilic pyrrole derivative facilitates the entrapment of the modified soluble PQQ-dependent glucose dehydrogenase into the Os-complex-modified polymer and hence allows for the development of reagentless biosensors. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate (cas: 14431-43-7Related Products of 14431-43-7).
(2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate (cas: 14431-43-7) belongs to tetrahydropyran derivatives. Numerous natural products have tetrahydropyran skeleton as the building block for designing new natural products and their derivatives e.g. aplysiatoxins, avermectins, oscillatoxins, talaromycins, latrunculins and acutiphycins. The Prins reaction of homoallylic alcohols with aldehydes afforded an alternative method for the preparation of tetrahydropyrans.Related Products of 14431-43-7
Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics