Sakamoto, Kaoru et al. published their research in Seito Gijutsu Kenkyu Kaishi in 2008 | CAS: 14431-43-7

(2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate (cas: 14431-43-7) belongs to tetrahydropyran derivatives. Dihydropyrans and tetrahydropyrans are examples of cyclic ethers widespread in nature. The most notable anticancer agent, bryostatin, and eribulin are marine macrolides having intriguing tetrahydropyran and furan motif. Electric Literature of C6H14O7

Observation of process of melting of glucose and lactose on heating by differential scanning calorimetry and microscopy was written by Sakamoto, Kaoru;Kishihara, Shiro;Sakuda, Harumi;Miura, Kayoko;Koizumi, Yae;Yamamura, Eiko. And the article was included in Seito Gijutsu Kenkyu Kaishi in 2008.Electric Literature of C6H14O7 This article mentions the following:

We have reported that in spite of the fact that the purity of com. granulated sugar is higher than 99.9% the sugars from different refineries have different m.ps., and also that they showed different melting profiles and different colored brown. These facts are a very curious phenomenon, when considering that crystal substances generally have their own specific m.ps. We looked at crystals of D-glucose and D-lactose instead of sucrose in this study. By differential scanning calorimetry (DSC) and microscopy, the process of melting by heating the two sugar crystals was observed Also by using a scanning electron micro-scope, the surface of the crystals was observed The m.p. of α-D-glucose monohydrate is accepted as 83° in the literature. For the α-D-glucose monohydrate used in this study, three peaks on the DSC endothermic curve were observed at around 80°, 122° and 154°. However, on heating the α-D-glucose monohydrate, the crystal did not melt at 83°, and melted partially at 126° and completely at 158°. The temperature, at which the crystal melted completely, was close to m.p. of β-D-glucose anhydride in the literature. The m.p. of α-D-lactose monohydrate in the literature is 201-202°. The DSC-endothermic curves for the crystals of the α-D-lactose monohydrate used in this study had two sharp peaks at 146° and 219°. In the microscopic observation, melting of the crystals was not observed at the temperature (146°) of the first peak on the DSC endothermic curve nor at the m.p. (201-202°) reported in the literature. It was observed that α-D-lactose monohydrate began to turn brown, and began to partially melt at around the second peak (219°) and completely melted at 229°. After the α-D-glucose monohydrate and the α-D-lactose monohydrate were dried at 105° and 120°, resp., the resp. first peaks had a tendency to disappear or become small. On the observation with scanning electron microscope, both of the dried mono-hydrates had a lot of cracks on the crystal surface, which were possibly caused by the release of water mols. from the interior of the crystals. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate (cas: 14431-43-7Electric Literature of C6H14O7).

(2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate (cas: 14431-43-7) belongs to tetrahydropyran derivatives. Dihydropyrans and tetrahydropyrans are examples of cyclic ethers widespread in nature. The most notable anticancer agent, bryostatin, and eribulin are marine macrolides having intriguing tetrahydropyran and furan motif. Electric Literature of C6H14O7

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics