127956-11-0, Methyl 4-oxotetrahydro-2H-pyran-3-carboxylate is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A mixture of 2 (1.58 g, 10 mmol) and ammonium acetate (2.3 g, 30 mmol) in of MeOH (20 mL) was stirred overnight at room temperature. The mixture was concentrated under vacuum, dichloromethane (100 mL) and water (20 mL) were added, and the separated organic layer was dried over sodium sulfate and concentrated in vacuo. The crude product 3 was dissolved in 20 mL of CH3CN and treated with 2,2,2-trichloro-acetyl isocyanate (3.76 g, 20 mmol) and the mixture was stirred for 30 minutes. The resulting solid was collected by filtration and dissolved in NH3 in MeOH (8 mL, 7 N), the mixture was heated at 70C. After cooling to room temperature, a solid formed and was collected by filtration to give compound 4 (1.2 g, 71%). 1H NMR (300 MHz, DMSO-d6): delta 10.98 (br, 2H), 4.19 (s, 2H), 3.76 (t, J = 5.4 Hz, 2H), 2.38 (t, J = 5.4 Hz, 2H).
127956-11-0, 127956-11-0 Methyl 4-oxotetrahydro-2H-pyran-3-carboxylate 14666555, aTetrahydropyrans compound, is more and more widely used in various fields.
Reference£º
Patent; ZHOU, Han-Jie; PARLATI, Francesco; WUSTROW, David; WO2014/15291; (2014); A1;,
Tetrahydropyran – Wikipedia
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