125552-89-8, 4-(Bromomethyl)tetrahydropyran is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,125552-89-8
To a stirred solution of Intermediate 3 (250 mg, 1 mmol) and 4-(bromomethyl)tetrahydro-2H-pyran (449 mg, 2.51 mmol) in anhydrous MeCN (7 mL)was added dipotassium carbonate (347 mg, 2.51 mmol). The reaction mixture wasstirred overnight at 100C, cooled to RT, filtered through Celite and concentrated under reduced pressure. The resulting material was purified by chromatography using si[ica ge[ (gradient: hexane/EE) to give 1.0 g (76 % yie[d) of the tit[e compound as a co[our[ess oi[.1H NMR (500MHz, CDC[3): 6 [ppm] 8.08 (t, J = 1.4 Hz, 1H), 7.69-7.67 (m, 1H), 7.57 (dd, J = 2.5, 1.4 Hz, 1H), 7.53 – 7.51 (m, 1H), 4.05 – 4.00 (m, 2H), 3.94 (s, 3H),3.92 (d, J = 6.5 Hz, 2H), 3.49 – 3.42 (m, 2H), 2.53 – 2.52 (m, 3H), 2.14 – 2.03 (m,1H), 1.80- 1.75 (m, 2H), 1.53- 1.43 (m, 2H).LCMS (Ana[ytica[ Method A) Rt = 1 .45 min, MS (ESipos): m/z = 348 (M+H).
125552-89-8 4-(Bromomethyl)tetrahydropyran 2773286, aTetrahydropyrans compound, is more and more widely used in various fields.
Reference£º
Patent; EVOTEC AG; DAVENPORT, Adam James; BRAEUER, Nico; FISCHER, Oliver Martin; ROTGERI, Andrea; ROTTMANN, Antje; NEAGOE, Ioana; NAGEL, Jens; GODINHO-COELHO, Anne-Marie; (703 pag.)WO2016/91776; (2016); A1;,
Tetrahydropyran – Wikipedia
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