Comparative studies on the antimicrobial activity of α,β-unsaturated aldehydes was written by Beilfuss, Wolfgang. And the article was included in Zentralblatt fuer Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene, Abteilung 1: Originale, Reihe A: Medizinische Mikrobiologie und Parasitologie in 1976.Synthetic Route of C6H8O2 This article mentions the following:
Dilute emulsions of 15 straight-chain, branched-chain, or cyclic, α, β-unsaturated aldehydes were tested for antimicrobial activity against bacteria (including Bacillus subtilis spores and Mycobacterium smegmatis), fungi, and yeasts. The straight-chain compounds had a somewhat greater bacteriostatic and fungistatic action than did the branched-chain compounds Considerable structure-activity dependencies were found with respect to germicidal action: the activity increased with increasing number of total C atoms, reaching a maximum at C8-10; α-alkyl-substituted compounds had the best germicidal action. Compounds with high activity and broad spectrum of action included 2-ethyl-2-hexenal [645-62-5], 2-isopropyl-5-methyl-2-hexenal [35158-25-9], and 2-propyl-2-heptenal [34880-43-8], which showed especially good effect against B. subtilis spores and M. smegmatis. In the experiment, the researchers used many compounds, for example, 5,6-Dihydro-2H-pyran-3-carbaldehyde (cas: 13417-49-7Synthetic Route of C6H8O2).
5,6-Dihydro-2H-pyran-3-carbaldehyde (cas: 13417-49-7) belongs to tetrahydropyran derivatives. Tetrahydropyran is a useful synthetic intermediate. Tetrahydropyranyl (THP-) ethers derived from the reaction of alcohols and dihydropyran are common intermediates in organic synthesis. There is large number of marine macrolide natural products that contain tetrahydropyran and tetrahydrofuran ring together. For instance, goniodomin A (actin targeting polyether), prorocentrolide (toxin halistatins), and percentotoxineSynthetic Route of C6H8O2
Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics