Influence of excipients and storage humidity on the deposition of disodium cromoglycate (DSCG) in the Twin Impinger was written by Braun, Martin A.;Oschmann, R.;Schmidt, Peter. C.. And the article was included in International Journal of Pharmaceutics in 1996.Computed Properties of C6H14O7 This article mentions the following:
The in vitro deposition pattern of disodium cromoglycate (DSCG) from a unit dose dry powder inhaler device (Microhaler) was investigated using the Twin Impinger. Four excipients with differing particle sizes, two α-lactose monohydrate grades (Pharmatose 325 M, x50 = 56.3 μm and Granulac 220, x50 = 15.6 μm) and two dextrose monohydrate grades (Roferose FF, x50 = 102.8 μm and Roferose SF, x50 = 37.4 μm), were mixed with DSCG in the ratio 1 plus 1 and 1 plus 4 at low relative humidity. Loose spherical agglomerates were formed in a rotating drum and then the mixtures were filled into hard gelatin capsules size 3 and stored at 33 and 55% RH, resp. The deposition pattern was investigated using the Twin Impinger at a flow rate of 60 l/min. The amount of DSCG deposited in the lower impingement chamber, corresponding to a particle size of ≤6.4 μm, was markedly influenced by the humidity level during storage. In all experiments, the fine particle fraction from mixtures stored at 33% RH was higher compared to those stored at 55% RH. Mixtures containing 1 part DSCG plus 1 part excipient showed higher deposition rates than the 4+1 mixtures Excipients with a smaller mean particle diameter gave a higher DSCG deposition in the lower impingement chamber. Best results were obtained with the 1+1 mixtures of DSCG and fine lactose (Granulac 220) with 41% and DSCG and fine glucose (Roferose SF) with 38%, resp. The results indicate that dry powder inhalations can be optimized by appropriate selection of the excipient, because its particle size distribution and its proportion in a formulation in combination with the storage humidity are important factors determining the inhalation fraction of a formulation. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate (cas: 14431-43-7Computed Properties of C6H14O7).
(2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate (cas: 14431-43-7) belongs to tetrahydropyran derivatives. Tetrahydropyran is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and dyestuff. 2-(Arylmethylene)cyclopropylcarbinols could be converted to the corresponding tetrahydropyrans stereoselectively in the presence of Brønsted acids under mild conditions. A plausible Prins-type reaction mechanism has been proposed.Computed Properties of C6H14O7
Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics