Fragment-Based Discovery of 5-Arylisatin-Based Inhibitors of Matrix Metalloproteinases 2 and 13 was written by Agamennone, Mariangela;Belov, Dmitry S.;Laghezza, Antonio;Ivanov, Vladimir N.;Novoselov, Anton M.;Andreev, Ivan A.;Ratmanova, Nina K.;Altieri, Andrea;Tortorella, Paolo;Kurkin, Alexander V.. And the article was included in ChemMedChem in 2016.Quality Control of 3-[(2-Tetrahydropyranyl)oxy]phenylboronic Acid This article mentions the following:
Matrix metalloproteinases (MMPs) are well-established targets for several pathologies. In particular, MMP-2 and MMP-13 play a prominent role in cancer progression. In this study, a structure-based screening campaign was applied to prioritize metalloproteinase-oriented fragments. This computational model was applied to a representative fragment set from the publicly available EDASA Scientific compound library. These fragments were prioritized, and the top-ranking hits were tested in a biol. assay to validate the model. Two scaffolds showed consistent activity in the assay, and the isatin-based compounds were the most interesting. These latter fragments have significant potential as tools for the design and realization of novel MMP inhibitors. In addition to their micromolar activity, the chem. synthesis affords flexible and creative access to their analogs. In the experiment, the researchers used many compounds, for example, 3-[(2-Tetrahydropyranyl)oxy]phenylboronic Acid (cas: 1287777-05-2Quality Control of 3-[(2-Tetrahydropyranyl)oxy]phenylboronic Acid).
3-[(2-Tetrahydropyranyl)oxy]phenylboronic Acid (cas: 1287777-05-2) belongs to tetrahydropyran derivatives. Tetrahydropyran is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and dyestuff. Pyran derivatives such as pyran flavonoids are biologically important. Monosaccharides containing six-membered rings are called pyranose.Quality Control of 3-[(2-Tetrahydropyranyl)oxy]phenylboronic Acid
Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics