Phenylphosphinic acid-promoted addition of isocyanide to 1-methoxyisochroman derivatives was written by Soeta, Takahiro;Matsuzaki, Syunsuke;Ukaji, Yutaka. And the article was included in Heterocycles in 2018.Formula: C6H12O2 This article mentions the following:
A synthetic method for preparation of isochroman-1-carboxylamides I [R1 = H, 5-Me, 7-Br, etc.; R2 = t-Bu, Ph, Bn, etc.] was developed in good to high yields by addition of isocyanides to 1-methoxyisochroman derivatives in the presence of phosphinic acid. A wide range of 1-methoxyisochroman derivatives and isocyanides were suitable for this Passerini-type reaction. In the experiment, the researchers used many compounds, for example, 2-Methoxytetrahydro-2H-pyran (cas: 6581-66-4Formula: C6H12O2).
2-Methoxytetrahydro-2H-pyran (cas: 6581-66-4) belongs to tetrahydropyran derivatives. Numerous natural products have tetrahydropyran skeleton as the building block for designing new natural products and their derivatives e.g. aplysiatoxins, avermectins, oscillatoxins, talaromycins, latrunculins and acutiphycins. The reaction of tertiary 1,4- and 1,5-diols with cerium ammonium nitrate at room temperature gives tetrahydrofuran and tetrahydropyran derivatives in high yield and stereoselectivity. Various fragrant compounds have been synthesized using this method.Formula: C6H12O2
Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics