Antioxidant properties of swertiamarin, from Enicostemma littorale blume. leaves studied in high fat diet fed and low dose streptozotocin induced diabetic rats was written by Selvam, R.;Muruganantham, K.;Subramanian, S.. And the article was included in Asian Journal of Pharmacy and Pharmacology in 2019.HPLC of Formula: 17388-39-5 This article mentions the following:
Type 2 diabetes mellitus (T2DM) is an endocrine disorder characterized by insulin resistance, 尾 cell dysfunction, visceral obesity, inflammation and chronic oxidative stress. However, insulin resistance is predominant in type 2 DM which results in persistent hyperglycemia. Chronic hyperglycemia promotes auto-oxidation of glucose to form free radicals. The generation of free radicals beyond the scavenging abilities of endogenous antioxidant defenses results in the development of both macro- and microvascular complications. In present study, we have evaluated the antioxidant property of swertiamarin, a secoiridoid glycoside present in the Enicostemma littorale blume leaves in High fat fed and -Low dose streptozotocin induced type 2 diabetic rats. High-fat diet-fed and low-dose STZ was used to induce exptl. type 2 diabetes in rats. Diabetic rats were orally treated with swertiamarin (50 mg/kg b.w./rat/day) for 30 days. The levels of oxidative stress markers such as lipid peroxides, hydroperoxides and protein carbonyls were determined The levels of both enzymic as well as non enzymic antioxidants were evaluated. Diabetic rats showed significantly increased levels of oxidative stress markers and declined levels of both enzymic and non enzymic antioxidants. Oral treatment of swertiamarin at a concentration of 50mg/kg bw/rat/day for 30 days decreased the levels of oxidative stress markers and improved the status of antioxidants in diabetic rats indicating the antioxidant properties of swertiamarin in addition to its antidiabetic properties. In the experiment, the researchers used many compounds, for example, (4aR,5R,6S)-4a-Hydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-5-vinyl-4,4a,5,6-tetrahydropyrano[3,4-c]pyran-1(3H)-one (cas: 17388-39-5HPLC of Formula: 17388-39-5).
(4aR,5R,6S)-4a-Hydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-5-vinyl-4,4a,5,6-tetrahydropyrano[3,4-c]pyran-1(3H)-one (cas: 17388-39-5) belongs to tetrahydropyran derivatives. Tetrahydropyran is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and dyestuff. There is large number of marine macrolide natural products that contain tetrahydropyran and tetrahydrofuran ring together. For instance, goniodomin A (actin targeting polyether), prorocentrolide (toxin halistatins), and percentotoxineHPLC of Formula: 17388-39-5
Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics