A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells was written by Niphakis, Micah J.;Lum, Kenneth M.;Cognetta, Armand B. III;Correia, Bruno E.;Ichu, Taka-Aki;Olucha, Jose;Brown, Steven J.;Kundu, Soumajit;Piscitelli, Fabiana;Rosen, Hugh;Cravatt, Benjamin F.. And the article was included in Cell (Cambridge, MA, United States) in 2015.Related Products of 40365-61-5 This article mentions the following:
Lipids play central roles in physiol. and disease, where their structural, metabolic, and signaling functions often arise from interactions with proteins. Here, the authors describe a set of lipid-based chem. proteomic probes and their global interaction map in mammalian cells. These interactions involve hundreds of proteins from diverse functional classes and frequently occur at sites of drug action. The authors determine the target profiles for several drugs across the lipid-interaction proteome, revealing that its ligandable content extends far beyond traditionally defined categories of druggable proteins. In further support of this finding, the authors describe a selective ligand for the lipid-binding protein nucleobindin-1 (NUCB1) and show that this compound perturbs the hydrolytic and oxidative metabolism of endocannabinoids in cells. The described chem. proteomic platform thus provides an integrated path to both discover and pharmacol. characterize a wide range of proteins that participate in lipid pathways in cells. In the experiment, the researchers used many compounds, for example, 2-(But-3-yn-1-yloxy)tetrahydro-2H-pyran (cas: 40365-61-5Related Products of 40365-61-5).
2-(But-3-yn-1-yloxy)tetrahydro-2H-pyran (cas: 40365-61-5) belongs to tetrahydropyran derivatives. Dihydropyrans and tetrahydropyrans are examples of cyclic ethers widespread in nature. One classic procedure for the organic synthesis of tetrahydropyran is by hydrogenation of the 3,4-isomer of dihydropyran with Raney nickel.Related Products of 40365-61-5
Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics