Graphene oxide conjugated with doxorubicin: Synthesis, bioactivity, and biosafety was written by Abdelhalim, Abdelsattar O. E.;Ageev, Sergei V.;Petrov, Andrey V.;Meshcheriakov, Anatolii A.;Luttsev, Mikhail D.;Vasina, Lubov V.;Nashchekina, Iuliia A.;Murin, Igor V.;Molchanov, Oleg E.;Maistrenko, Dmitrii N.;Potanin, Artem A.;Semenov, Konstantin N.;Sharoyko, Vladimir V.. And the article was included in Journal of Molecular Liquids in 2022.Electric Literature of C56H92O29 This article mentions the following:
This work presents a method for covalent functionalization of GO with a cytostatic preparation DOX with a loading of 87%. The resulting nanomaterial was characterized using modern physicochem. methods (13C NMR, Raman, IR, UV/Vis spectroscopy, XPS, XRD, HRTEM). The synthesized conjugate showed significant antiaggregating activity and selective cytotoxicity towards the A549 cell line, significantly superior to individual DOX, as well as low cytotoxicity towards the non-cancer cell line HEK293. The complex biocompatibility study was conducted for the synthesized conjugate including hemocompatibility study, antioxidant activity, interaction with HSA and DNA, geno- and cytotoxicity investigation. At the same time, mol. dynamics investigation was performed in order to determine the features of intermol. interaction between GO and DOX mols. In the experiment, the researchers used many compounds, for example, Digitonin (cas: 11024-24-1Electric Literature of C56H92O29).
Digitonin (cas: 11024-24-1) belongs to tetrahydropyran derivatives. Tetrahydropyrans are also used as important solvents, as chemical intermediate and as monomer for ring-opening polymerization. The reaction of tertiary 1,4- and 1,5-diols with cerium ammonium nitrate at room temperature gives tetrahydrofuran and tetrahydropyran derivatives in high yield and stereoselectivity. Various fragrant compounds have been synthesized using this method.Electric Literature of C56H92O29
Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics