Wang, Min-xiu et al. published their research in Acta Pharmacologica Sinica | CAS: 9008-22-4

Laminarin (cas: 9008-22-4) belongs to tetrahydropyran derivatives. Tetrahydropyrans are useful synthons for biologically important compounds. The most notable anticancer agent, bryostatin, and eribulin are marine macrolides having intriguing tetrahydropyran and furan motif. Quality Control of Laminarin

Dectin-1 plays a deleterious role in high fat diet-induced NAFLD of mice through enhancing macrophage activation was written by Wang, Min-xiu;Luo, Wu;Ye, Lin;Jin, Lei-ming;Yang, Bin;Zhang, Qian-hui;Qian, Jian-chang;Wang, Yi;Zhang, Yi;Liang, Guang. And the article was included in Acta Pharmacologica Sinica.Quality Control of Laminarin This article mentions the following:

The innate immune response and inflammation contribute to hepatic steatosis and non-alc. fatty liver disease (NAFLD). Dectin-1 is a pathogen recognition receptor in innate immunity. In this study, author investigated the role of Dectin-1 in the pathogenesis of NAFLD. Author first showed that Dectin-1 expression was significantly elevated in liver tissues of patients with NASH. NAFLD was induced in mice by feeding high fat diet (HFD) for 24 wk. At the end of treatment, mice were sacrificed, and their blood and liver tissues were collected for anal. Author showed HFD feeding also increased liver Dectin-1 levels in mice, associated with macrophage infiltration. Either gene knockout or co-administration of a Dectin-1 antagonist laminarin (150 mg/kg twice a day, i.p., from 16th week to 24th week) largely protected the livers from HFD-induced lipid accumulation, fibrosis, and elaboration of inflammatory responses. In primary mouse peritoneal macrophages (MPMs), challenge with palmitate (PA, 200 μM), an abundant saturated fatty acid found in NAFLD, significantly activated Dectin-1 signaling pathway, followed by transcriptionally regulated production of pro-inflammatory cytokines. Dectin-1 was required for hepatic macrophage activation and inflammatory factor induction. Condition media generated from Dectin-1 deficient macrophages failed to cause hepatocyte lipid accumulation and hepatic stellate activation. In conclusion, this study provides the primary evidence supporting a deleterious role for Dectin-1 in NAFLD through enhancing macrophage pro-inflammatory responses and suggests that it can be targeted to prevent inflammatory NAFLD. In the experiment, the researchers used many compounds, for example, Laminarin (cas: 9008-22-4Quality Control of Laminarin).

Laminarin (cas: 9008-22-4) belongs to tetrahydropyran derivatives. Tetrahydropyrans are useful synthons for biologically important compounds. The most notable anticancer agent, bryostatin, and eribulin are marine macrolides having intriguing tetrahydropyran and furan motif. Quality Control of Laminarin

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics