Functionalised Graphene Quantum Dots for Cholesterol Detection in Human Blood Serum was written by Ayilliath, Shanti Krishna;Nair, Sreekanth Radhakrishnan;Lakshmi, Gopu Chandrasekharan;Kunnatheery, Sreenivasan. And the article was included in Journal of Fluorescence in 2021.Electric Literature of C56H92O29 This article mentions the following:
The varied applications of nanotechnol. have paved way for several breakthroughs in the realm of biomedical technol. In this challenging era when illness multiplies, timely and accurate disease diagnosis is very important. Thus, well founded novel approaches matter very much in areas like disease diagnosis and monitoring. Nanomedicine has tremendous implications in the given context. An elevated cholesterol concentration in blood is risky and is associated with cardiovascular diseases (CVD). CVD remains the Number 1 global cause of death and hence there is an urge to understand cholesterol level and take preventive measures. Highly fluorescent graphene quantum dots (GQs) are well known for their biocompatibility, non toxicity and aqueous solubility Here in we report an easy and sensitive non enzymic based cholesterol detection using digitonin conjugated graphene quantum dots (GDG). Selectivity studies and the cholesterol detection in human blood serum suggests the probe to be reliable and selective for blood cholesterol monitoring. In the experiment, the researchers used many compounds, for example, Digitonin (cas: 11024-24-1Electric Literature of C56H92O29).
Digitonin (cas: 11024-24-1) belongs to tetrahydropyran derivatives. Tetrahydropyrans are useful synthons for biologically important compounds. 2-(Arylmethylene)cyclopropylcarbinols could be converted to the corresponding tetrahydropyrans stereoselectively in the presence of Brønsted acids under mild conditions. A plausible Prins-type reaction mechanism has been proposed.Electric Literature of C56H92O29
Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics